High "Normal" Blood Glucose Is Associated with Decreased Brain Volume and Cognitive Performance in the 60s: The PATH through Life Study
- Mortby, ME
- Janke, AL
- Anstey, KJ
- Sachdev, PS
- Cherbuin, N
DOIAbstract
Context:Type 2 diabetes is associated with cerebral atrophy, cognitive impairment and dementia. We recently showed higher glucose levels in the normal range not to be free of adverse effects and to be associated with greater hippocampal and amygdalar atrophy in older community-dwelling individuals free of diabetes.Objective:This study aimed to determine whether blood glucose levels in the normal range (<6.1 mmol/L) were associated with cerebral volumes in structures other than the hippocampus and amygdale, and whether these glucose-related regional volumes were associated with cognitive performance.Design, Setting and Participants:210 cognitively healthy individuals (68-73 years) without diabetes, glucose intolerance or metabolic syndrome w...
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